1. Don’t Waste Time or Words * Don’t spend more time on a task than you need. * Don’t say more than you need. Efficiency matters. Medicine trains you to process large amounts of information quickly. Save your energy for what’s important. 2. Conserve Your Resources Ask yourself:
Medical students face a unique challenge: learning an enormous amount of material in a short time. The expectation is not to master every detail, but to build a strong foundation—to know enough to recognize what is wrong, what is common, and what needs urgent attention. 1. Breadth vs. Depth
1. Pathways of Activation There are three pathways of complement activation. All converge at C3 cleavage. Classical Pathway * Triggered by antibody-antigen complexes (IgM, IgG) or C-reactive protein (CRP). * C1 complex = C1q + 2 C1r + 2 C1s. * Activation requires ≥2 Fc regions bound. * C1s cleaves C4 → C4a + C4b and C2 → C2a + C2b.